Experimental inoculation of 4‑week‑old BALB/c mice (intraperitoneal, 10⁴ PFU) produced a transient, low‑grade viremia (peak 10³ RNA copies mL⁻¹) lasting 3–4 days, without overt clinical signs. In contrast, 2‑day‑old SPF (specific‑pathogen‑free) chickens displayed mild conjunctivitis and a modest fever (≈1 °C rise) for 2 days post‑infection, suggesting a higher pathogenic potential in avian species. No mortality was observed in either model.
While MIDV‑075 currently appears to cause only mild or subclinical disease, its capacity for genetic reassortment (given its segmented ancestry) could enable the emergence of more virulent variants. Moreover, the virus’s ability to infect both avian and mammalian cells makes it a candidate bridge pathogen capable of crossing species barriers, particularly in settings where humans, livestock, and wildlife interact closely (e.g., backyard poultry farms). MIDV-075
A risk‑assessment framework should therefore consider: While MIDV‑075 currently appears to cause only mild
| Metric | Test Condition | Result | |--------|----------------|--------| | Endurance (max payload) | 12 kg, 30 °C, 0 % humidity | 45 min | | Max Speed | Level flight, 12 kg | 125 km/h | | Video Latency (1080 p) | On‑board inference | 28 ms | | LiDAR Point‑Cloud Rate | 300 k pts/s, 10 Hz output | 15 ms processing | | Object Detection (YOLO‑v8) | 1080 p @ 120 fps | 35 ms per frame | | Power Consumption (full load) | All sensors + compute | 380 W | | Metric | Test Condition | Result |
All tests were conducted on the MIDV‑075 prototype (Serial #A1B2C3) in a controlled indoor flight arena.