Yes, but that’s different. With a Windows To Go drive (Windows installed entirely on a fast USB SSD), you boot the entire operating system from the USB. Then, you install Fusion 360 normally inside that portable Windows environment. This works perfectly but requires:
Autodesk uses a sophisticated licensing system (FlexNet or Named User). This system writes machine-specific identifiers to the registry and hidden folders (e.g., C:\ProgramData\FLEXnet). If you try to run Fusion 360 from a USB drive on a different computer, the licensing server sees a "new device" and often requires re-activation—which can consume one of your device slots. autodesk+fusion+360+portable+install
You cannot create a "plug-and-play" portable executable (.exe) for Fusion 360 in the same way you can for Notepad++ or 7-Zip. Yes, but that’s different